Miss Miller takes the boys to see Savage Squids from Outer Space while Dave is visiting Paris and the Chipettes are camping away from the city. Miss Miller accidentally breaks Simon's glasses the night before Simon is to be named science student of the year for creating an ultra powerful telescope. That night Theodore is scared and Alvin takes a look out of Simon's telescope (as they believe tonight would be the only night they could arrive). Alvin and Simon claim to have seen a killer squid coming towards Earth. They rush to the police station and when the reporting officer doesn't believe their story, the boys sneak into the dispatchers office to alert the entire force. After they are discovered, they rent a plane to inform the public. They call Dave before heading to Simon's banquet at which Simon discovers that there was just an earwig on the end of his telescope.
- "Purple People Eater" originally performed by Sheb Wooley.
- The title is a reference to the game Simon Says.
- This episode once again shows Miss Miller's poor driving; this time she hits a fire hydrant.
- The savage squids resemble insects more than squids.
- Miss Miller's flying is no better than her driving.