Clyde is a tall and slim man with pale skin and a long, pointed nose. He has a dark nose-stache and matching hair that stands aloft. Being a scientist, he wears a body length, long-sleeved lab coat, black pants, and shoes.
Clyde is a bold man who seeks to improve life by inventing things that unfortunately already exist leading to interesting results. He sometimes sees himself much more intelligent than his assistant though Leonardo's advice typically is more logical. Despite this, Clyde cares for Leonardo's well-being and values him similar to that of a friend.
- Clyde's first invention was the wine press, which he created at the age of four.
- In Alvin and the Chipmunks Meet the Wolfman, The Chipmunks and The Chipettes attend Clyde C. Crashcup Elementary School.
He also appears in the 1981 special A Chipmunk Christmas, during a dream sequence, and the 1990 The Chipmunks Go to the Movies episode Back to Our Future, in which he takes the modern day Chipmunks back in time to meet their 1958 selves (technically 1960s selves).